Berkeley Lab's Molecular Biophysics & Integrated Bioimaging Division has an immediate opening for an XFEL (X-ray Free-Electron Laser) Computational Crystallographer Postdoctoral Fellow. The next decade of structural biology at the Linac Coherent Light Source (LCLS) will include groundbreaking advances in time domain protein crystallography, diffuse scattering to observe dynamic motion, and single particle diffraction, and we are developing the data-centered computational methods that will make these advances possible.
What You Will Do:
Serial crystallography datasets carry many challenges, in particular the sheer volume of data, and the special treatment required for still-shot Bragg reflections. We are seeking a scientist with strong physical and mathematical intuition who can formulate and code the appropriate algorithms for data processing, and who has the patience and drive to deal with the many experimental uncertainties and sources of noise. The successful candidate will join a team of developers focused on software for new science, building on a strong pre-existing software foundation, including the DIALS and cctbx.xfel toolkits created here (http://cci.lbl.gov/publications/nick_sauter.html).
One focus area is photosystem II, using a combination of time-resolved XFEL-based crystallography and X-ray emission spectroscopy to elucidate the sequence of redox events leading to the release of molecular oxygen. Our Division is involved in all aspects of the project, including experimental design and construction, data collection, software development, and crystallographic analysis. Another critical area is the examination of other metalloenzymes such as nitrogenase. Crystallography can spatially resolve the absorption edges from distinct metal centers in the catalytic cofactors, and the absorption spectrum will inform us about the electronic environment and valence states of the atoms. XFELs afford us time resolution, and assure the absence of radiation damage, but the anomalous differences must be quantified to better than 1%, thus creating a need for a unique, new software approach.
The projects are funded by a combination of NIH and DOE sources. We also have an ongoing DOE-funded collaboration with SLAC, to scale up the crystallography data analysis pipeline to petascale supercomputers here at NERSC, and eventually to exascale servers in the next decade. This is a great chance for personal growth in a highly collaborative environment, but candidates should come well prepared with a working knowledge of Python and C++, and attendant problem-solving skills.
What is Required:
PhD in Biophysics, Bioinformatics, Mathematics, Computer Science, Engineering or Physical Sciences.
Familiarity with macromolecular crystallography, other structural biology techniques, or image processing methods.
Python and C++ both mandatory.
Experience with modern object-oriented, version-controlled software development, with a team-oriented approach.
Excellent oral and written communication skills.
Ability to work effectively as part of a cross-disciplinary team.
Demonstrated ability to analyze complex problems with direct supervision, develop strategies to solve specific problems, while running appropriate controls to validate the correct results.
The posting shall remain open until the position is filled.
This is a full time, 2 years, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
Full-time, M-F, exempt (monthly paid) from overtime pay.
Salary will be predetermined based on postdoctoral step rates.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
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Internal Number: 84324
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.