The Stanford Cancer Institute (SCI) at Stanford University is seeking a highly motivated Life Science Research Professional 2 to join the Pegram Lab with an interest in elucidating drug resistance mechanisms in breast cancer. Current research efforts include a continued focus on the cancer-associated gene that encodes HER2 and developing new ways to target cancer cells expressing this protein. To achieve this, the Pegram lab employs a multidisciplinary approach involving human genetics, molecular and cell biology and immunology.
The ideal LSRP candidate will have a 5-year specific clinical experience in related breast cancer field and an excellent translational perspective to translate unmet clinical needs into novel basic science projects and interpret scientific findings in clinical-based context. Successful candidate must be well organized and able to conduct experiments, which involve gene cloning, expression and manipulation; lentivirus transduction; cell culture and structural, functional assays via various cell biology techniques; functional analysis of purified proteins including sequence analysis, activity assays in vitro/vivo; immunohistochemistry/immunofluorescence staining on fixed cell/tissue and confocal fluorescent microscopy operation; and other molecular assays on primary mammalian cancer cells. The LRSP will maintain cultured cells, prepare assay reagents and samples, create novel plasmid constructs, and perform molecular assays, which will require working knowledge of mammalian cell culture and molecular biology. The position will also require some maintenance of standard lab equipment and supplies. The LRSP will work under general guidance from the Principal Investigator, and will also work closely with other researchers in a team setting. The LRSP must be accurate, efficient, organized, keep detailed records, have excellent communication skills, and must have the ability to recognize irregularities in experimental results and modify experiments accordingly.
Perform complex (lab and/or field) experiments for a major portion of the research project. Maintain detailed records of experiments and outcomes.
Interpret and analyze results, often where few guidelines exist. Based on prior results, contribute to development of new research protocols and procedures or adaptation of existing protocols.
Make recommendations on plan design and/or research direction to principal investigator.
Work with health and safety department to ensure lab complies with regulations and all required trainings.
Participate in multidisciplinary teams across different faculties or schools.
Oversee supply and equipment budget under supervision of principal investigator or business manager.
Perform ongoing literature review to remain current with new procedures and related research; present findings for lab work group.
Contribute substantively to the preparation of papers for publication, especially in the results section. May contribute to publication of findings and present ongoing work and findings to colleagues at academic conferences.
Supervise (either formally or informally) staff or students as needed, including oversight and instruction on techniques, as well as consultation on project work. Serve as technical resource for other research staff.
Perform general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains d...edicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 9000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu.
Stanford University is an equal opportunity employer and is committed to increasing the diversity of its faculty. It welcomes nominations of and applications from women, members of minority groups, protected veterans and individuals with disabilities, as well as from others who would bring additional dimensions to the university’s research, teaching and clinical missions.