The Stanford Cancer Institute (SCI) at Stanford University is seeking a highly motivated Life Science Research Professional 2 to join the Pegram Lab with an interest in elucidating drug resistance mechanisms in breast cancer. Current research efforts include a continued focus on the cancer-associated gene that encodes HER2 and developing new ways to target cancer cells expressing this protein. To achieve this, the Pegram lab employs a multidisciplinary approach involving human genetics, molecular and cell biology and immunology.
The ideal LSRP candidate will have a 5-year specific clinical experience in related breast cancer field and an excellent translational perspective to translate unmet clinical needs into novel basic science projects and interpret scientific findings in clinical-based context. Successful candidate must be well organized and able to conduct experiments, which involve gene cloning, expression and manipulation; lentivirus transduction; cell culture and structural, functional assays via various cell biology techniques; functional analysis of purified proteins including sequence analysis, activity assays in vitro/vivo; immunohistochemistry/immunofluorescence staining on fixed cell/tissue and confocal fluorescent microscopy operation; and other molecular assays on primary mammalian cancer cells. The LRSP will maintain cultured cells, prepare assay reagents and samples, create novel plasmid constructs, and perform molecular assays, which will require working knowledge of mammalian cell culture and molecular biology. The position will also require some maintenance of standard lab equipment and supplies. The LRSP will work under general guidance from the Principal Investigator, and will also work closely with other researchers in a team setting. The LRSP must be accurate, efficient, organized, keep detailed records, have excellent communication skills, and must have the ability to recognize irregularities in experimental results and modify experiments accordingly.
Perform complex (lab and/or field) experiments for a major portion of the research project. Maintain detailed records of experiments and outcomes.
Interpret and analyze results, often where few guidelines exist. Based on prior results, contribute to development of new research protocols and procedures or adaptation of existing protocols.
Make recommendations on plan design and/or research direction to principal investigator.
Work with health and safety department to ensure lab complies with regulations and all required trainings.
Participate in multidisciplinary teams across different faculties or schools.
Oversee supply and equipment budget under supervision of principal investigator or business manager.
Perform ongoing literature review to remain current with new procedures and related research; present findings for lab work group.
Contribute substantively to the preparation of papers for publication, especially in the results section. May contribute to publication of findings and present ongoing work and findings to colleagues at academic conferences.
Supervise (either formally or informally) staff or students as needed, including oversight and instruction on techniques, as well as consultation on project work. Serve as technical resource for other research staff.
Perform general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
* - Other duties may also be assigned.
The candidate must have a bachelor's degree in biology, biotechnology, biochemistry or related scientific field, or preferably medical doctor's.
The candidate should have at least five years of specific clinical experience in related breast cancer field and have an excellent translational perspective to translate unmet clinical needs into novel basic science projects and interpret scientific findings in clinical-based context.
The candidate should have at least two years of specialized research experience with molecular and cell biology techniques including gene cloning, expression and manipulation; lentivirus handling; cell culture and structural, functional assays; functional analysis of purified proteins including sequence analysis, activity assays in vitro/vivo; immunohistochemistry/immunofluorescence staining on fixed-cell/tissue and confocal fluorescent microscopy operation, etc., in which s/he demonstrated the ability to work under supervision, show self-initiative, attention to details and a strong motivation to explore new techniques and concepts.
Proficiency with medical statistics software to perform clinical and basic research data analysis via SPSS, Image J, Graphpad Prism, etc. to generate publishing-quality figures/tables and precisely interpret the scientific findings.
Team Oriented, strong communication skills, excellent written and oral presentation skills and adherence to highest ethical principles when working with laboratory animals is necessary to be considered.
Ability to work under deadlines and willingness to work outside normal business hours as necessary are a prerequisite. In addition, strong organizational and logistical skills with respect to data and supply management are required.
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and three years of related experience, or Master's degree. KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Strong analytical skills and excellent judgment.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to accurately complete detailed work.
CERTIFICATIONS & LICENSES:
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs.
WORK STANDARDS (from JDL):
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
Location: School of Medicine Schedule: Full-time Classification Level:
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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