The laboratory of Dr. Christopher Garcia at Stanford University is seeking a highly motivated Life Science Research Professional 2 (LSRP 2) to perform complex functions and activities involved in defined research projects, and independently conduct a portion of such research. Dr. Garcia's laboratory is interested in the molecular basis for how cell-surface receptors interact with and respond to extracellular stimuli, and in engineering novel ligands to manipulate signaling pathways in immunology, cancer and stem cell biology. Receptors under study include T cell receptor, MHC, cytokine receptors, Wnt, Notch, and others.
Working in parallel with the lab's post-doctoral fellows, the LSRP 2 will independently perform complex experiments involved in defined research projects as assigned by Dr. Garcia. These projects will principally involve gene construct design and cloning, protein expression and purification from insect and mammalian cells. Protein engineering via yeast surface display and phage display will also be expected and involve library design and selections. The LSRP 2 is expected to independently conduct, analyze, and present experiments in coordination with the postdoctoral fellows in the laboratory.
Perform complex experiments for a major portion of the research project. Maintain detailed records of experiments and outcomes. Areas of candidate's expertise must include:
oBasic Molecular Biology, PCR, Plasmid preparation, Construction of expression vectors for production of Recombinant Proteins
oTissue culture and transfections of Mammalian and Insect cells
oExpression, purification and production of Recombinant Proteins in bacterial, insect and mammalian systems.
oYeast Surface Display and Phage Display, Library design and selections.
Interpret and analyze results, often where few guidelines exist. Based on prior results, contribute to development of new research protocols and procedures or adaptation of existing protocols.
Make recommendations on plan design and/or research direction to principal investigator.
Perform ongoing literature review to remain current with new procedures and related research; present findings for lab work group.
Contribute substantively to the preparation of papers for publication, especially in the results section. May contribute to publication of findings and present ongoing work and findings to colleagues at academic conferences.
Supervise (either formally or informally) staff or students as needed, including oversight and instruction on techniques, as well as consultation on project work. Serve as technical resource for other research staff.
Perform general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
* - Other duties may also be assigned
DESIRED QUALIFICATIONS: - Degree in Biology, Molecular Biology, Biochemistry or related field-Experienced in molecular biology and protein biochemistry-Highly motivated, dedicated, and independent-Strong team player-Excellent written and oral communication skills-3+ years of research experience in a specific related field
EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and three years of related experience, or Master's degree. KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Strong analytical skills and excellent judgment.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to accurately complete detailed work. CERTIFICATIONS & LICENSES: None PHYSICAL REQUIREMENTS*:
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion. * - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job. WORKING CONDITIONS:
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs. WORK STANDARDS:
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
Location: School of Medicine, California, United States Schedule: Classification Level:
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 9000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu.Stanford University is an eq...ual opportunity employer and is committed to increasing the diversity of its faculty. It welcomes nominations of and applications from women, members of minority groups, protected veterans and individuals with disabilities, as well as from others who would bring additional dimensions to the university’s research, teaching and clinical missions.