Research Bioinformatician I performs general bioinformatics analysis and software support for projects involving in omics, and interact with investigators to identify research problems, find appropriate software tools, and recognize national biological databases and online resources for omic data. The RB will manage omic data including loading and querying data from database system and public repositories and transform and merge multilevel omic data into user-friendly formats, assist in development, test, and maintenance of modular software pipelines, provide bioinformatics data analysis, preliminary interpretation of the data, and reports of the results for possible publications. Research Bioinformatician will also work with bioinformatics faculties to determine future bioinformatics needs, and helps to develop tools and pipelines as necessary to keep pace with rapid advances in sequencing technology. The Bioinformatician will demonstrate continuous self-improvement, make effective contributions to the section, and adhere to CSHS compliance plan, code of conduct, and hospital and departmental policies and procedures. He/she may serve as a preceptor for students. The RB will also provide statistical services for investigators, clinical trials, including performance of statistical analyses, preparation of data sets and writing of statistical results. The RB is responsible for the performance of statistical analyses, preparation of data sets and writing of statistical results. The RB is responsible for the statistical aspects of research projects including documentation of statistical methods, review of validation checks and providing reports to the Research Team. This position coordinates the statistics deliverables of ongoing research studies, ensures study timelines are met, reviews data for adherence to protocol, interacts with project coordinators to share knowledge of the data and provides statistical programming support to scientific programming personnel as required. Interacts with research scientists, EIS Analyst, study coordinators and data entry personnel in analyzing results, interpreting biostatistical findings, collecting and gathering information for formulating programs. The RB will demonstrate continuous self-improvement, make effective contributions to the section, and adhere to CSHS compliance plan, code of conduct, and hospital and departmental policies and procedures.
ESSENTIAL JOB DUTIES AND RESPONSIBILITIES: Analyzes and interprets findings relating to research and/or clinical trials according to established practices and in compliance with HIPAA guidelines. Performs basis statistical tests including parametric, non-parametric, multi-variate, regression and correlation analyses. Performs a variety of increasingly complex biostatistical programming and analytical assignments. Provides consultation to Principal Investigators, Research Scientists, Research Nurses, and other related research staff, and applies biostatistics to standard and complex research projects. May assists or collaborate in preparation of grant proposals, protocol designs, publications, and presentations. Constructs, cleans and manages databases that contain data on family structures, biologic traits and genetic markers. These data will be obtained from multiple sources involving coordination with collaborators from off-campus sites. Trains data entry staff in particular database management programs, as necessary, according to study protocols and in compliance with HIPAA guidelines. Provides general bioinformatics analysis support for omic projects and mainly responsible for data analysis and software compilations including next generation sequence alignment, polymorphism identification, expression analysis, and visualization tools and browsers. Summarizes data analyses results in the form suitable as the basis for the first draft of written reports, and makes preliminary interpretations of the data. Develop, test, and maintain modular software pipelines for genome sequencing, assembly, annotation, metagenomic analysis, and genotyping using high-throughput sequencing platforms including 454, Illumina, and Pacific Biosciences Manages data including loading and querying data from database systems, downloading omic data from public repositories, and transforming data to the necessary formats Familiar with medical and biological terminologies, bioinformatics resources, and national biological databases, Ready to provide solutions for investigator's problems through data mining and extraction
Identify, evaluate, and incorporate relevant algorithms and software pipelines by reviewing pertinent literatures in bioinformatics and computational biology Assists or collaborate in preparation of grant proposals, publications, and presentations involving omic data
Helps develop tools and pipelines as necessary to keep pace with rapid advances in sequencing technology.
Educate others about bioinformatics through mentoring of and teaching colleagues, investigators, fellows, and graduate students.
Analyzing health care and health care claims data using basic and advanced statistical methodologies/programming and preparing reports. Being able to perform statistical analysis on a range of research projects including basic, translational, clinical and population-based research.
Data processing for accurate relocation, formatting, importing and exporting data using STATA and SAS software.
Data cleaning. Revisions to data entry screens and data checks. review and resolution of data discrepancies
Strong interpersonal and communication skills to work effectively with research scientists, biostatisticians, and data entry personnel.
Ability to apply theoretical knowledge to unusual or complex projects.
EDUCATIONAL AND WORK EXPERIENCE PREFERENCES:
Thorough, demonstrated knowledge of database and biostatistical computer programs, such as SAS, Stata and Excel
Any combination of academic education, professional training or work experience, which demonstrates the ability to perform the duties required for the position.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.