This position will remain open until a successful candidate has been identified.
UCSD Layoff from Career Appointment: Apply by 10/22/2019 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 10/31/2019. Eligible Special Selection clients should contact their Disability Counselor for assistance.
The Moores Cancer Center is one of just 49 in the United States to hold a National Cancer Institute (NCI) designation as a Comprehensive Cancer Center. As such, it ranks among the top centers in the nation conducting basic and clinical cancer research, providing advanced patient care and serving the community through outreach and education programs.
The Cancer Center's mission is to translate promising scientific discoveries into new and better options for the care of patients with cancer. The Center supports one of the broadest ranges of cancer activities in the nation – from fundamental and translational cancer research in molecular genetics and advanced molecular therapeutics, and from population studies of cancer incidence to community education about cancer prevention and risk reduction.
Oversee and conduct tumor biology studies consisting of murine models of cancer, animal breeding and genotyping, immunohistochemistry, in vitro cell biology, and in vitro biochemistry. Murine tumor biology studies will include xenograft, orthotopic and spontaneous tumor growth and metastasis assays, treatment of animals with experimental therapeutic agents, breeding and genotyping of transgenic and mutant mice, bone marrow transplantation and cell isolations. Perform major surgery, including small animal anesthesia.
In addition, perform specialized cell biology techniques such as cell migration assays, cell-substrate adhesion assays, cell-cell adhesion assays and immunohistochemistry of frozen and fixed tissues or cells. Conduct various cell culture techniques to include performing flow cytometry analysis of cell surface protein expression, transfecting cells with expression constructs, preparing lysates of cells in culture or tissues. Conduct various protein biochemistry techniques to include quantification, ELISA assays, SDS PAGE, Western and Immunoblotting, phosphorylations, and gel electrophoresis. Additionally, perform recombinant DNA techniques to include preparing plasmids and maintaining plasmid stocks, analyzing DNA and RNA purification, and conducting DNA electrophoresis,and RT-PCR.
Perform immunohistochemistry of frozen and fixed sections. Make significant innovative contributions regarding experimental design and methodology by reviewing published scientific data in referred journals, as well as online using search engines and subject-specific websites, to make recommended changes to current protocols and practices. Troubleshoot problems for quality control on immunochemical and histochemical procedures. Maintain and prepare accurate records of all experiments. Assist in the preparation of data for publication. Assume responsibility for lab maintenance. Provide training and work direction in areas of expertise as needed. Maintain and prepare accurate records of all experiments. Assist in the preparation of data for publication.
Experience in mouse handling, breeding, genotyping and tumor growth and metastasis assays, including performing immunohistochemistry of frozen and fixed sections.
Experience with and willingness to perform surgery, including small animal anesthesia.
Experience working with immune and tumor cell isolations.
Knowledge in tissue culture techniques, including specialized assays such as cell migrations assays, cell-substrate adhesion assays, cell-cell adhesion assays immunocytochemistry and transfection.
Experience and knowledge in recombinant DNA techniques including conducting plasmid preparation and maintenance of plasmid stocks; performing DNA and RNA purification, DNA electrophoresis and RT-PCR.
Experience with protein biochemistry techniques; including quantification, ELISA assays, SDS PAGE, Western and Immunoblotting, phosphorylations and gel electrophoresis.
Demonstrated ability to design, develop and implement new research and experimental techniques to meet research objectives.
Strong communication skills (verbal and written) needed to interact professionally and effectively in the work environment. Effectively and accurately document research procedures. Ability to read, comprehend, and discuss research materials.
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 8 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom - life is their laboratory. UC San Diego's rich academic portfolio includes six undergraduate colleges, five academic divisions and five graduate and professional schools. The university's award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs.