The England Laboratory within the Department of Pharmaceutical Chemistry seeks candidates for a Specialist research position with expertise in cellular and molecular biology. Qualified applicants will be hired at the Junior, Assistant, or Associate level, depending upon the candidate’s experience. Dr. England’s research is focused on developing chemical probes and potential drug leads for nuclear receptors, a class of intracellular proteins that regulate gene expression in response to endogenous hormones and other small molecules. These receptors play critical roles in human development, physiology, and disease and have proven to be effective therapeutic drug targets. Under general direction, the incumbent will characterize the activity of ligands targeting the nuclear receptor Nurr1, a potential therapeutic target for Parkinson’s disease, and LRH-1, a potential therapeutic target for several cancers. The incumbent will also design and utilize constructs to study the oligomerization of these nuclear receptors with intracellular proteins. Applicants are expected to be able to work independently and possess the ability to read and digest literature surrounding their project, and to troubleshoot experiments when they don’t work. In addition, the applicant must possess the ability to analyze their data and clearly communicate their research techniques and results in written and oral formats suitable for publication. Specific activities associated with the position include, but are not limited to, the following:
Cellular assays (cultured cells). Technical skill set: aseptic cell culture procedures, DNA cloning, primer design for PCR, rtPCR, qPCR.
Cellular assays (neurons). Technical skill set: preparation of acute dissociated neurons from mice.
Cellular imaging assays. Technical skill set: live and fixed cell imaging.
Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree).
Specialists appointed at the Assistant or Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of research experience.
Two or more years prior experience conducting laboratory research.
Excellent organizational skills
Excellent written and verbal presentation skills
Experience with graphing software (e.g. Excel, Prism or KaleidaGraph) and statistical analyses, powerpoint or other oral presentation software.
Applicants must list all of the basic qualifications (or if pending) on their CV and/or cover letter upon submission.
Candidates must meet the requirements by the time of appointment.
PhD (or equivalent level of experience) in cellular and molecular biology, biochemistry, neuroscience, or equivalent area.
UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
Internal Number: JPF02871
About University of California, San Francisco
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.