Postdoctoral Scientist - Pituitary - Melmed Lab in Los Angeles, CA for Cedars-Sinai Medical Center

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Postdoctoral Scientist - Pituitary - Melmed Lab

Cedars-Sinai Medical Center

Details

Posted: 14-Aug-21

Location: Los Angeles, California

Type: Full-time

Salary: Open

Internal Number: HRC0630452

Principal Investigator, Dr. Shlomo Melmed is looking for a Postdoctoral Scientist to join his team!

The Melmed Laboratory focuses on elucidating mechanisms of pituitary tumor development and pathogenesis, translating the study of anterior pituitary function regulation to the clinic and establishing new modalities of diagnosis and treatment for pituitary diseases. Examples of work in the Melmed Lab include acromegaly therapeutic targeting via somatostatin receptor signaling, Cushing disease drug discovery using a zebrafish model for screening of small molecules, and characterization of the human pituitary tumor-transforming gene, critical to pituitary tumor cell cycle outgrowth. The Melmed Laboratory is affiliated with the Medicine Department and Pituitary Center.

To learn more about Dr. Melmed's research, please visit: Melmed Research Lab | Cedars-Sinai.

Working independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientist, the Postdoctoral Scientist will perform routine and complex laboratory procedures throughout the training period. A Postdoctoral Scientist may also develop, adapt, and implement new research techniques and protocols, analyze and interpret data, and may assist in the preparation of grant proposals but is not responsible for generating grant funding.

Primary Job Duties and Responsibilities:

Investigate the mechanisms of pituitary tumorigenesis.
May participate in publications and presentations as author or co-author.
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
Analyzes, interprets, summarizes and compiles data.
Operates and maintains equipment and instruments.
Specific laboratory procedures including: Plasmid construction, DNA/RNA/protein extraction, SDS-polyacrylamide gel electrophoresis, western blotting, immunoprecipitation, luciferase reporter gene assay, site-directed mutagenesis, Glutathione S-transferase (GST) pull-down experiments, PCR, RT-PCR, quantitative real-time PCR, ELISA, IgG purification, DNA digestion, DNA amplification, ligation and subcloning, DNA or siRNA transfection, direct sequencing, mammalian cell culture and transfection, blood and organ collection (from rats and mice), isolation of primary hepatocyte (rat), primary culture of anterior pituitary cells (mice), injection into tail vein of mice, in vivo knockdown experiment by antisense oligonucleotide.

Education:

Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization, required.

Experience and Skillset:

Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, operation and maintenance of specialized equipment
Knowledge of safety standards.

Working Title: Postdoctoral Scientist - Pituitary - Melmed Lab
Department: Home Dept - Melmed Lab
Business Entity: Academic / Research
City: Los Angeles
Job Category: Academic/Research
Job Specialty: Postdoctoral
Position Type: Full-time
Shift Length: 8 hour shift
Shift Type: Day

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About Cedars-Sinai Medical Center

Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.

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