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Research Scientist, Protein Engineering

Stanford University

Details

Posted: 21-Apr-23

Location: Stanford, California

Type: Full-time

Salary: Open

Internal Number: 98730

Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking discoveries that advance our understanding of and ability to improve human health. Sarafan ChEM-H has partnered with Stanford Medicine to launch a bold new translational research initiative - Stanford's Innovative Medicines Accelerator (IMA). IMA aims to accelerate the translation of scientific discoveries at Stanford University into new therapeutics that impact human health while improving our understanding of human biology.

Our VPDoR Diversity Journey:

* We create a hub of innovation through the power of diversity of disciplines and people.

* We provide equitable access and opportunity to all members of the community in order to do their best work, regardless of race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

* We listen to and value all colleagues who bring diverse perspectives to the advancement and development of a respectful community.

* We promote a culture of belonging, equity, and safety.

* We embed these values in excellence of education, research, and operation.

POSITION SUMMARY:

We are seeking a highly motivated scientist to serve as the Research Scientist in Protein Engineering for the Sarafan ChEM-H Knowledge Centers, a series of collaborative research facilities that promote translation of scientific discoveries through access to expertise, mentorship, and equipment. Your work will focus primarily on providing molecular biology support, DNA library construction, protein production, and high-throughput protein optimization using directed evolution techniques. You will also lead several projects ongoing in the lab that are focused on developing novel protein platforms for a variety of applications. Are you capable, interested in performing essential functions and activities involved in defined research projects, and able to independently conduct and analyze experiments? Then help us to forge a new generation of custom-made protein tools and therapeutics!

CORE DUTIES:

* Lead the planning, design, and implementation of drug discovery initiatives, and work toward project objectives.

* Support complex scientific and research programs related to protein engineering..

* Analyze data, monitor and oversee experimental processes, and design and develop drug prototypes, specialized methods, and/or assays.

* Collaborate with scientists, engineers, or senior administrative officers to oversee complex non-routine analyses of drug discovery processes, select optimum solutions, and perform corrective modifications to strategies, workflows and applied methods.

* Carry out all activities, including troubleshooting and resolving routine problems in protein engineering, independently.

* Collaborate with senior scientists to design and develop special purpose equipment, methods and/or assays

* Oversee a laboratory space or unit, and supervise the work of technicians and other staff associated with the group.

* Serve as a resource in review of research proposals and research capabilities, and make recommendations.

* Establish, communicate, and enforce compliance with health and safety policies and procedures.

* Develop training manuals and safety guidelines, and train new instrumentation users, researchers, and/or technical staff.

* Perform supervisory duties, including overseeing the work of technicians and other staff associated with the group/project, supervising the regular installation, maintenance, and operation of complex scientific or engineering projects, and training technicians, operators, and others working in particular scientific or engineering function area.

MINIMUM REQUIREMENTS:

Education & Experience:

Bachelors' degree in engineering, science, or related field, or five years of equivalent work experience or combination of education and relevant experience.

Preferred qualifications:

* PhD in immunology, cell biology, biochemistry, chemistry or any closely related field and 3 or more years of academic / industry experience.

* Experience in the biotech or pharma industry is a plus.

Knowledge, Skills and Abilities:

* Expert knowledge and skills of advanced protein engineering principles and practices, especially in directed evolution and display technologies.

* Experience in cellular assay development.

* In-depth understanding of cell biology, immunology and biochemistry.

* Used to generate and applying computational predictions and structural analysis in drug discovery projects (e.g. Schrodinger, MOE, and/or Rosetta)

* Demonstrated ability to perform experiments independently by applying the highest scientific standards.

* Ability to collaborate with senior engineering and scientific staff to design and develop special purpose equipment and/or systems.

* In-depth understanding of drug discovery processes

* Experience in overseeing the plan, design, and implementation of drug discovery initiatives and ensuring that project objectives are met.

* Demonstrated ability to review research proposals, evaluate research capabilities, and make recommendations.

* Proven record to effectively supervise and train a diverse work staff, PostDocs and PhD students.

* Experience overseeing a laboratory space or unit and supervising the work of technicians and other staff associated with the group.

* Demonstrated ability to effectively supervise and train a diverse work staff.

* Ability to independently oversee and manage instrumentation or system installation.

PHYSICAL REQUIREMENTS*:

* Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.

* Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.

* Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh >40 pounds.

* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job.

WORKING CONDITIONS:

* May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights ?10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.

* May require travel.

WORK STANDARDS:

* Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.

* Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.

* Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.

The expected pay range for this position is $104,000 to $129,000 per annum.

Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

Why Stanford is for You

Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:

* Freedom to grow. We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.

* A caring culture. We provide superb retirement plans, generous time-off, and family care resources.

* A healthier you. Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.

* Discovery and fun. Stroll through historic sculptures, trails, and museums.

* Enviable resources. Enjoy free commuter programs, ridesharing incentives, discounts and more!

The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

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About Stanford University

Why work at Stanford?Stanford University has changed the world, over and over again.We are one of Silicon Valley's largest employers - and also one of the most unique. Our mission is to educate future leaders and promote interdisciplinary, world-class research and teaching. This passion makes Stanford an intensely creative, rewarding, and challenging place to work. At the same time, our traditions of respect and collaboration sustain a humane, supportive environment in which to pursue your life and your career.At Stanford you'll work with bright, diverse, dedicated people. You'll find encouragement to learn and grow. You'll enjoy excellent benefits and an outstanding environment. How will it change you?

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