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Junior Specialist in Membrane Protein Biochemistry and Biophysics
University of California Davis
Details
Posted: 24-May-23
Location: Davis, California
Type: Full-time
Salary: Open
Internal Number: 4208848
Junior Specialist in Membrane Protein Biochemistry and Biophysics
This position will be involved in interdisciplinary studies focusing on questions in membrane transporter biology, structural biology, molecular toxicology, and protein biochemistry. Successful candidates will also participate in laboratory studies, sampling and working with human tissue, sampling and working with life honey bees, toxicokinetic data analysis and mining. The ideal candidate will have strong interpersonal, communication, and decision-making skills; as well as the ability to work well independently and as part of a team.
General responsibilities include:
Assay support (80%):
The JS will perform drug transporter gene cloning & expression in bacterial (E. coli) and yeast (Pichia) vectors, transform those microbial cells with codon-optimized transporter gene constructs, perform controlled biofermentation (protein expression), affinity and size exclusion FPLC for membrane protein purification, and conduct membrane transporter activity assays to validate functional proteins. The JS is expected to develop a Design of Experiment (DOE) document for each drug transporter cloning, expression, and purification experiment. This document will include all optimization steps necessary for successful protein expression and activity measurements. Optimization strategies for each experimental section, will be discussed weekly in 1:1 meeting with the PI. The JS is expected to independently develop backup plans for possible experimental pitfalls, such as alternative expression systems and host organisms for membrane proteins or alterative antibody selections for western blotting.
Laboratory operations support (10%):
The JS is expected to participate in general lab maintenance and safety procedures. These operations include preparation of experimental stock solutions (buffers, reagents). Maintaining notebooks, instrument logbooks, and records. Maintaining inventory levels of protein expression and purification supplies; reorder as required. The JS is further expected to become Subject Matter Expert (SME) for the BioRad FPLC and Eppendorf BioFlow 120 bio-fermentation units in the lab. This will include weekly instrumental performance checks and correspondence with the manufacturer to schedule and assist in annual Preventative Maintenance (PM).
Analytical Summary Reports (10%):
The JS is expected to present results in weekly lab meetings and provide poster or oral presentations on scientific conferences in the fields of Membrane Biophysics and Molecular Toxicology (i.e., Annual meetings of the Society of Toxicology (SOT), Society of Environmental Toxicology and Chemistry (SETAC), and Biophysical Society). The JS is expected to become a professional member of NorCal SETAC. The JS will further assist in reviewing and editing language and figures for conference abstracts, journal manuscripts, and research proposals. The JS is expected to publish both, the optimized membrane protein expression and purification protocols and the functional characterization of each active membrane protein in peer review journals related to Environmental and Human Health and Structure-Function Analysis of Membrane Proteins.
To apply, visit https://recruit.ucdavis.edu/JPF05730
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About University of California Davis
UC Davis is the home of the Aggies — go-getters, change makers and problem solvers who make their mark at one of the top public universities in the United States. Since we first opened in 1908, we’ve been known for standout academics, sustainability and Aggie Pride as well as valuing the Northern California lifestyle. These themes are woven into our 100-plus-year history and our reputation for solving problems related to food, health, the environment and society.Our 5,300-acre campus is in the city of Davis, a vibrant college town of about 68,000 located in Yolo County. The state capital is 20 minutes away, and world-class destinations such as the San Francisco Bay Area, Lake Tahoe and the Napa Valley are within a two-hour drive.
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https://careers.cbia.org/jobs/18625613/junior-specialist-in-membrane-protein-biochemistry-and-biophysics
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