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Life Science Research Professional 2

Stanford University

Details

Posted: 29-Jul-23

Location: Stanford, California

Type: Full-time

Salary: Open

Internal Number: 100087

Life Science Research Professional 2

The School of Humanities and Sciences (H&S) is the foundation of a liberal arts education at Stanford. The school encompasses 23 departments and 25 interdisciplinary programs. H&S is home to fundamental and applied research, where free, open, and critical inquiry is pursued across disciplines. As the university's largest school, H&S serves as the foundation of a Stanford undergraduate education no matter which discipline students pursue as a major. Graduate students work alongside world-renowned faculty to pursue and shape foundational research that leads to breakthroughs and discoveries that shed new light on the past, influence the present, and shape the future. Together, faculty and students in H&S engage in inspirational teaching, learning, and research every day.

Position Summary:

What makes us human? The Fraser Lab in the Department of Biology at Stanford University is seeking a Basic Life Science Research Professional 2 (undergraduate or masters-level) to help us answer this question. We use human-chimpanzee "hybrid" induced pluripotent stem cells and cutting-edge CRISPR-based tools to understand the genetics behind uniquely human traits such as our bigger brains and much higher risk for Alzheimer's disease and schizophrenia. Previous work using these hybrid stem cells-- a novel platform recently developed in our lab-- showed that a change in the expression of a single gene is responsible for our unique facial structure and introduced human-chimpanzee hybrid brain organoids as a powerful model for studying the evolution of the human brain (see https://rdcu.be/c0Pj5 and https://rdcu.be/c0Pka for the publications).

In the lab, you will work closely with other lab members as well as the principal investigator and be heavily involved in the planning, execution, and publication of exciting science. In general, the day-to-day work in the position will focus on the construction and validation of plasmids used to alter the expression of human and chimpanzee genes using CRISPR and the generation of libraries for RNA sequencing. In addition, there will be the opportunity to learn and apply powerful techniques such as stem cell culture and differentiation. A small amount of time will be devoted to lab organization/safety. Overall, this is an excellent opportunity for anyone with an undergraduate or masters degree and previous experience with molecular biology techniques. Familiarity with mammalian stem cell culture or CRISPR-based approaches is a plus but is not required.

Past Research Professionals in the lab have published first-author papers in top journals like Cell and have gone on to PhD programs at Stanford as well as exciting positions in industry. We are fully committed to helping all lab members accomplish their professional goals by developing skills sought after in both academia and industry, providing recommendation letters, and helping to craft compelling applications. We especially encourage people from backgrounds historically underrepresented in science to apply. We hope you'll join us to help discover the answers to age-old questions about what makes us human.

This is a 1-year fixed term position with the possibility of renewal. This position will be based on the Stanford campus.

If you believe that this opportunity is a match for your knowledge, skills and abilities, we encourage you to apply. Thank you for considering employment opportunities with the School of Humanities and Sciences.

CORE DUTIES:

* Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.

* Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.

* Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.

* Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.

* Participate in multidisciplinary teams across different faculties or schools.

* Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.

* Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.

* Oversee supply and equipment budget under supervision of principal investigator or business manager.

* Work with health and safety department to ensure lab complies with regulations and all required trainings.

* Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.

* Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.

* Other duties may also be assigned.

EDUCATION AND EXPERIENCE:

* Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.

KNOWLEDGE, SKILLS, AND ABILITIES:

* Comprehensive understanding of scientific principles.

* General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.

* Strong analytical skills and excellent judgment.

* Ability to maintain detailed records of experiments and outcomes.

* Ability to work under deadlines with general guidance is essential.

* Excellent organizational skills and demonstrated ability to accurately complete detailed work.

In addition, preferred requirements include:

* Experience with lentivirus generation and infection

* Experience with induced pluripotent stem cells maintenance and manipulation

WORKING CONDITIONS:

* May require working in close proximity to blood borne pathogens.

* May require work in an environment where animals are used for teaching and research.

* Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

* Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

* May require extended or unusual work hours based on research requirements and business needs.

The expected pay range for this position is $67,000 to $88,000 per annum.

Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will

be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.

Why Stanford is for You

Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:

* Freedom to grow. We offer career development programs, tuition reimbursement, or audit a course. Join a film screening, or listen to a renowned author or global leader speak.

* A caring culture. We provide superb retirement plans, generous time-off, and family care resources.

* A healthier you. Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.

* Discovery and fun. Stroll through historic sculptures, trails, and museums.

* Enviable resources. Enjoy free commuter programs, ridesharing incentives, discounts and more.

The job duties listed are typical examples of work performed by positions in this job classifications and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.

Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of their job.

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

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About Stanford University

Why work at Stanford?Stanford University has changed the world, over and over again.We are one of Silicon Valley's largest employers - and also one of the most unique. Our mission is to educate future leaders and promote interdisciplinary, world-class research and teaching. This passion makes Stanford an intensely creative, rewarding, and challenging place to work. At the same time, our traditions of respect and collaboration sustain a humane, supportive environment in which to pursue your life and your career.At Stanford you'll work with bright, diverse, dedicated people. You'll find encouragement to learn and grow. You'll enjoy excellent benefits and an outstanding environment. How will it change you?

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